Rats in which MK-801, an N-methyl-d-aspartate antagonist, was preadministered also were used. Background and stretch reflex activities of the bilateral oblique abdominal, psoas, and quadratus lumborum muscles were recorded. Muscle stretch elicited by bending of the lumbar spine was applied as a test stimulus. In spinalized rats (transection of the spinal cord), the sciatic nerve was stimulated electrically as a conditioning stimulus. Recently, prolonged alteration of motor function in the hindlimbs of animals caused by central sensitization has been reported. The neuronal mechanism of sciatic scoliosis has not been well clarified. Sciatic scoliosis usually occurs with convexity to the side of the herniated disc. To verify the hypotheses that sciatic scoliosis is induced reflexively by radiculopathic pain, and that scoliosis might be maintained by prolonged asymmetric alteration of the trunk muscle tonus caused by central sensitization of the spinal neurons that constitute the postural reflex pathways. The effects of electrical stimulation of the sciatic nerve on background electromyographic and static stretch reflex activity of the trunk muscles were studied.
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